More about Dr. Hochgeschwender:

Dr. Hochgeschwender's CV in brief

Publications

Molecular, Cell and Developmental Biology Research Program

Ute Hochgeschwender, M.D. Associate Member, Molecular, Cell and Developmental Biology Research   Program Director, Mouse Genome Manipulation Facility Adjunct Associate Professor, Department of Cell Biology, University of Oklahoma   Health Sciences Center Adjunct Associate Professor, Oklahoma Center for Neuroscience

Research Interests
Our research goal is to study the molecular mechanisms of human diseases through the study of normal and aberrant development and function of model organisms. Our research approach is the generation of mouse mutants with the goal of creating in vivo experimental models from which we can learn more about the molecular mechanisms underlying function and dysfunction of the organism. The generation of mouse models utilizes molecular biological and transgenic technologies; the analysis of mouse models includes anatomical, biochemical, physiological, and behavioral studies.

We have generated a number of mouse mutant strains through targeted mutagenesis in embryonic stem cells. We are currently focusing our research on the analysis of a mouse mutant lacking proopiomelanocortin (POMC). POMC gene products are associated with a wide variety of functions, including energy homeostasis, lipolysis, adrenal maintenance and function, enhancement of learning and memory, anti-inflammatory effects and alteration of pigmentation. Accordingly, several projects in the laboratory are concerned with the detailed phenotype analysis of the POMC null mutant model (see publications listed below).

The underlying motivation for our studies is less the reduction of biological processes to basic interactions, but rather the understanding of the integration of biological processes into complex homeostases.

Joined OMRF Scientific Staff in 1998.

Mailing Address
Molecular, Cell and Developmental Biology Research Program, MS 49
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, Oklahoma 73104

Contact Information
Phone: (405) 271-7318
Fax: (405) 271-7220
E-mail: Ute-Hochgeschwender@omrf.org