Core Facilities

Animal Models Core Facility

BIACORE

Clinical Immunology
Laboratory

Crystallography

Myositis Testing

DNA Sequencing

Flow Cytometry

Imaging Core Facility

Microarray Research
Facility

Nuclear Magnetic Resonance Core Facility

Signal Transduction
Core Facility

Shared Facilities

Laboratory Animal
Resource Center (LARC)

Institutional Animal
Care and Use
Committee (IACUC)

Crystallography visualizes molecular structures and components of living cells at atomic resolutions. We can then use their forms and shapes to further elucidate sequences of events in normal or disease states.

The primary emphasis of OMRF's Crystallography Core Facility is to provide an arena for studying and understanding the structures of biologically and biomedically relevant proteins. Structures are determined using X-ray diffraction coupled with interactive computer graphics. We make every effort to determine the biological relevance of these structures. We assess function, mechanisms of action and interactions between the proteins with other macromolecules in conjunction with crystallography through molecular biology applications such as mutagenesis and advanced biochemical and kinetic analysis.

This combined approach renders interpretable structure analysis capability. This is crucial, because it is no longer sufficient to know how structures and complexes appear; we must also understand how they work.

We endeavor to serve the needs of OMRF research programs and participate in special collaborative efforts outside the institution. Some of the research interests currently under investigation include three-dimensional structures of cardiovascular system-related macromolecular drugs, cellular metabolism and transport regulators along with their associated molecular partners.