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Dr. Kotake:

Dr. Kotake's CV in brief

Publications

Free Radical Biology and Aging Research Program

Yashige Kotake, Ph.D. Research Associate Member, Free Radical Biology and Aging Research   Program Adjunct Associate Professor, Department of Pharmaceutical Sciences, University of   Oklahoma Health Sciences Center

Research Interests
The goals of our studies is to understand the exact meaning of the term "antioxidant activity".  Antioxidants increasingly attract interest from general public because of the extension of lifespan in American population.  However, the meaning of the term 'antioxidant' remains vague and presently few scientific studies are being carried out on this subject.  In the field of food and agricultural science, a method to quantify 'oxygen radical absorbance capacity' (ORAC method) has been developed and ORAC values of more than 300 vegetables, fruits, and other foods are listed in the homepage of USDA.  However, the ORAC method is not a well-defined method.  Recently we have developed a scientifically well-defined method as a substitute for the ORAC method by using photochemical production of free radicals and their eradication by antioxidant (Anal. Biochem. 2009 386:167-71).  Electron paramagnetic resonance (EPR) spectroscopy was employed to quantify the amount of free radicals.  The new method is applied to the serum in chronic renal failure patients, indicating that the disease significantly alters sera's free radical scavenging activity.

Joined OMRF Scientific Staff in 1990.

Mailing Address
Free Radical Biology and Aging Research Program, MS 21
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, Oklahoma 73104

Contact Information
Phone: (405) 271-7570
Fax: (405) 271-1437
E-mail: Yashige-Kotake@omrf.org